Bile duct cancer, or cholangiocarcinoma, develops in the tubes that carry bile from the liver to the small intestine. Symptoms include jaundice (yellowing of skin and eyes), dark urine, pale stools, abdominal pain, weight loss, and itching. Risk factors include chronic bile duct inflammation, primary sclerosing cholangitis, liver fluke infections, and certain genetic conditions. Diagnosis involves blood tests, imaging scans, and biopsy. Treatment options depend on the stage and may include surgery, chemotherapy, radiation, or targeted therapy. Liver surgery offers the best chance for cure when the cancer is detected early and confined